Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment.
نویسندگان
چکیده
A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
منابع مشابه
Agnew, Lauren R. and Cruickshank, Dyanne L. and McGlone, Thomas and Wilson, Chick C. (2016) Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 46 شماره
صفحات -
تاریخ انتشار 2016